Relationship Between Protein Kinase C and Diabetic Nephropathy Patients in Al Anbar City

Abstract

Background : Diabetic syndrome is characterized by increase blood sugar and resistance to insulin. It is linked to macrovascular  and microvascular complications such as nephropathy, neuropathy, and retinopathy . the aim of this study to investigate the relationship protein kinase C and diabetic nephropathy.

Material and Methods: The study was  include  84 samples , 36  of them with type 2 diabetes, 23 of them with diabetic nephropathy, and 25  healthy controls population  , all of whom were over the age of 40. ELISA was used to calculate the protein kinase C level, fasting serum sugar , Glycated Hemoglobin ,Urea, Creatinine, Total protein, Albumin, and globulin were all found. Body mass index  was also calculated.

Result : the study result shown approximately  same level between healthy and patients groups and this also associated with increase in fasting serum sugar , Glycated Hemoglobin , Urea , Creatinine  and body mass index  in patients group compared to Healthy controls group.

Conclusion: serum protein kinase C shown non-significant difference between healthy and control patients.