Oxidative Stress and Decreased Serum Levels of Superoxide Dismutase (SOD) as a Potent Risk Factor for Thyroid Disease among Local Pregnant Females in Punjab

Abstract

Aim: To assess the potent role of oxidative stress biomarkers in pregnant females with thyroid disease.

Study design: Cross sectional comparative study.

Place and duration of study: Institute of Molecular Biology & Biotechnology (IMBB), The University of Lahore from 1^st July 2019 to 31^st July 2021.

Methods: The study was designed to compare serum levels of oxidative stress markers and serum antioxidant levels between pregnant females who had thyroid disease as comorbidity and euthyroid pregnant controls. The markers were measured in fifty cases and fifty control serum samples using various laboratory tests and ELISA kits. Samples were collected from PINUM, Faisalabad and Obstetrics & Gynaecology Department, DHQ Chiniot, Faisalabad division.

Results: Mean ages of cases and controls were 29.19±4.17 and. 26.07±4.88 years. The serum levels of SOD were significantly decreased (p≤0.001) in pregnant females having thyroid dysfunction (0.05± 0.01 nmol/ml) as compared to the control group (0.06±0.01nmol/ml). None of the other oxidative markers showed a significant difference between cases and controls (p>0.05).

Conclusion: The lower serum SOD levels may be a potential risk factor for the development of thyroid disease in local pregnant females.

Keywords: Oxidative stress, Thyroid-stimulating hormone, Thyroid dysfunction, Superoxide dismutase, malondialdehyde,