Effect of Preoperative Steroid Injection on Wound Drainage after Modified Radical Mastectomy

Authors

  • Muhammad Nasir Iqbal, Amir Usman, Sommayya Aftab, Mansab Ali, Syed Muhammad Mohsin Azeem, Wafa Najeeb

DOI:

https://doi.org/10.53350/pjmhs2023174394

Abstract

Background: After surgery for breast cancer, there is a risk of increased wound drainage and seroma formation. Various treatments are utilized to overcome this issue with variable effectiveness.

Objective: To compare the outcome of a single preoperative dose of intravenous steroid injection versus control group on wound drainage in patients undergoing modified radical mastectomy (MRM) for stage I and II breast cancer.

Methodology: It is a randomized control trial conducted over a period of 6 months. Total 60 patients who underwent MRM for carcinoma of breast were included. They were divided into 2 groups with each group having 30 cases. In group-A 120 mg (3 ml) of injection depomedrol was given one hour before surgery while in group B, 3 ml of normal saline was used, and MRM was performed and two drains were placed. At the time of drain removal, drainage volume was assessed in both groups.

Results: Mean age of the patients was 47.37.89 and the mean drainage volume in group A versus B was 672117.63 and 1020159.9 respectively. Among the patients, 51.7% had stage I and 48.3% had stage II breast cancer. The two groups had statistically significant difference in terms of mean drainage volume (p value =0.048).

Conclusion: In patients who underwent MRM, prophylactic steroid injection was associated with significant reduction in mean drainage volume compared to normal saline.

Keywords: Modified Radical Mastectomy, Steroid, Seroma Formation

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How to Cite

Muhammad Nasir Iqbal, Amir Usman, Sommayya Aftab, Mansab Ali, Syed Muhammad Mohsin Azeem, Wafa Najeeb. (2023). Effect of Preoperative Steroid Injection on Wound Drainage after Modified Radical Mastectomy. Pakistan Journal of Medical & Health Sciences, 17(04), 394. https://doi.org/10.53350/pjmhs2023174394