Comparison of the Efficacy of Letrozole and Clomiphene Citrate in women having Anovulatory Infertility

Authors

  • Aisha Ajmal, Joveria Sadaf, Sana Hafeez, Fareeha Usman, Aslam Mahmood Malik

DOI:

https://doi.org/10.53350/pjmhs202317233

Abstract

Aim: To compare the efficacy of letrozole and clomiphene citrate in women having anovulatory infertility.

Study design: Randomized Controlled Trial.

Place and duration of study: 16th October 2020 to 15th September 2021 in Department of Obstetrics & Gynecology, Shahida Islam Medical Complex Lodhran.

Methods: In our study 112 patients between ages 18 to 40 years with anovulation were included. Patients having H/O previous pelvic surgery, raised prolactin and TSH levels were excluded. These women were divided into02 groups i.e. Group A (clomiphene citrate) & Group B (letrozole), by lottery method and the effectiveness was noted in both groups.

Results: Mean age of women in group A was 24.53±6.12 years and in group B was 25.37±6.33 years. Majority women included in our study, 78(69.64%) were between ages 18 to 30 years. Duration of infertility was 3.28±2.11 years. Mean infertility duration in group A was 3.63±2.10 years and in group B was 3.79±2.14 years. The efficacy of drug shownin Group A was 9(8.03%) while in Group B was 18(16.07%) (p-value = 0.005).

Conclusion: We concluded from this study that letrozole is proved to be more efficacious than clomiphene citrate in anovulatory infertility.

Keywords: Anovulation, Infertility, Letrozole, Clomiphene Citrate, Conception Rate

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How to Cite

Aisha Ajmal, Joveria Sadaf, Sana Hafeez, Fareeha Usman, Aslam Mahmood Malik. (2023). Comparison of the Efficacy of Letrozole and Clomiphene Citrate in women having Anovulatory Infertility. Pakistan Journal of Medical & Health Sciences, 17(02), 33. https://doi.org/10.53350/pjmhs202317233

Issue

Vol. 17 No. 02 (2023): Pakistan Journal of Medical & Health Sciences

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Articles

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