Neuropathophysiological Mechanisms and Treatment Strategies for Post-Traumatic Epilepsy

Abstract

Aim: To understand and analyze neuropathophysiological mechanisms and treatment strategies for post traumatic epilepsy.

Study design: Cohort clinical trial study

Place and duration of study: Department of Neurosurgery, Chandka Medical College Hospital, Larkana 1^st January 2021 to 31^st March 2022.

Methodology: One hundred and twenty cases of traumatic brain injury were enrolled. In 1^st sub group there was 20 cases were given either Sodium valproate (SG1a) while 20 were given its placebo (SG1b). Similarly in subgroup 2^nd and 3^rd, each had 20 cases who were given Levetiracetam (SG2a) or Phenytoin (SG3a) respectively or other given its respective placebo (n=20/SG2b, SG3b). Primary and secondary outcomes were measured.

Results: The mean age was 30.1±3.3 years. There was almost equal number of both genders with slightly higher number of males than females with no significant variance. Around 40.83% of the cases were suffering from traumatic brain injury as a result of fall from a higher/raised building or structure.

Conclusion: The sodium valproate had a highest efficacy in controlling of the post-traumatic brain injury epileptic seizure not only for a short duration but for longer duration as well.

Keywords: Treatment strategies, Post-traumatic epilepsy, Neuropathophysiological mechanisms