Quantification of Endothelin-1 Gene Expression in the Diabetic Patients' Type II (DMT2) with Cardiovascular Disease

Authors

  • Mervat Kamil Kadhim, Alaa Mohammad Hasson Al-Husseini

DOI:

https://doi.org/10.53350/pjmhs221610423

Abstract

The goal of this study is to see if there's a link between diabetes type 2 problems and endothelin-1 overexpression (ET-1).

      Where (90) blood samples from participants were obtained and divided into three groups: a first group representing individuals with (Hypertensive DMT2) and a second group representing (Hypertensive DMT2with CVD,), while the third group was represented by a control group.

      mRNA was extracted from blood samples then converted to cDNA by using the (qPCR) technique. When comparing the levels of ET-1 in the (hypertensive DMT2 and hypertensive DMT2with CVD groups ) to the control group, the results showed a significant difference (p<0.05), The current study analyzed the ET-1 gene in type 2 diabetes and cardiovascular disease, which could be a new target for early CVD therapy in the future.

Keywords: endothelin-1gene, diabetes type II, cardiovascular disease, , endothelial dysfunction

Downloads

How to Cite

Mervat Kamil Kadhim, Alaa Mohammad Hasson Al-Husseini. (2022). Quantification of Endothelin-1 Gene Expression in the Diabetic Patients’ Type II (DMT2) with Cardiovascular Disease. Pakistan Journal of Medical & Health Sciences, 16(10), 423. https://doi.org/10.53350/pjmhs221610423

Issue

Vol. 16 No. 10 (2022): Pakistan Journal of Medical and Health Sciences

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

This is an open-access journal and all the published articles / items are distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.