Prognostic Significance of Lactate Dehydrogenase for in Hospital Mortality in Intensive Care Units with Covid-19 in Tertiary Care Level Hospital in Northern Pakistan

Authors

  • Haroon Ur Rasheed, Hayat Muhammad Khan, Mohsin Shafi, Naeemullah, Saeed Ahmad, Romana Ayub, Arif Iqbal, Muhammad Ishtiaq

DOI:

https://doi.org/10.53350/pjmhs22167843

Abstract

Background: Lactate dehydrogenase was found as the prognostic indicator of poor outcomes and severity of COVID-19. In many studies, COVID-19 patients with different LDH showed relationship with disease progression and mortality.

Objectives: To determine prognostic significance of Lactate dehydrogenase (LDH) in critically ill patients with Covid-19 infection.

Material & Methods: A retrospective descriptive cross sectional study was conducted among the Covid-19 ICU admitted patients of Khyber Teaching Hospital Peshawar. Moreover, data regarding n=233 COVID-19 serious infection, confirmed on Polymerase chain reaction (PCR), was analyzed. Prognostic significance of LDH was determined by using SPSS software.

Results: Compared to the survival group, LDH levels among the Covid-19 mortality individuals were significantly higher. A cutoff value of 330 U/L was set for the test results determined spectro-photometrically by chemistry analyzer. Chi-Square test value was 17.23 with P value of 0.004.

Conclusion: LDH is one of the cheap and significant prognostic parameter and is beneficial in forecasting hospital death in severely ill COVID-19 patients; may assist doctors focus on saving the lives of their highest-risk patients and apply new measures to lower mortality rates..

Keywords: Lactate Dehydrogenase, Prognostic Value, Mortality, Intense Care Unit, COVID-19

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How to Cite

Haroon Ur Rasheed, Hayat Muhammad Khan, Mohsin Shafi, Naeemullah, Saeed Ahmad, Romana Ayub, Arif Iqbal, Muhammad Ishtiaq. (2022). Prognostic Significance of Lactate Dehydrogenase for in Hospital Mortality in Intensive Care Units with Covid-19 in Tertiary Care Level Hospital in Northern Pakistan. Pakistan Journal of Medical & Health Sciences, 16(07), 843. https://doi.org/10.53350/pjmhs22167843

Issue

Vol. 16 No. 07 (2022): Pakistan Journal of Medical & Health Sciences

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Articles

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