Role of Pregabalin in Reducing Postoperative Analgesic Requirement of Patients Undergoing Knee Arthroscopy Anterior Cruciate Ligament Repair

Abstract

Objective: To assess the effect of pregabalin in reducing the postoperative requirement of analgesics of patient undergoing knee arthroscopic anterior cruciate ligament repair surgery.

Study Design: Prospective randomized control trial.

Place and Duration of Study: Department of Anesthesia, Ghurki Trust Teaching Hospital Lahore from 1^st June 2021 to 31^st December 2021.

Methodology: Eighty patients were randomly divided into two groups; group A and group B, each group comprised 40. Group A receive placebo and group B receive pregabalin 150mg once a day for two days after surgery. Pain assessment done with the help of Numeric Rating Scale and rescue analgesia was recorded.

Results: The mean age was 31±10.2 years of group A and 33±10.3 year of Group B. There were more males within both groups in comparison to females with a percentage of 77.5% and 85% respectively. The reduction was seen within Group B in comparison of Group A in terms of ASA class, VNRS, and maximum sensory block. Cumulative volume of PCA in ml was also less in group B than group A with a significant difference within 0-6 hours.

Conclusions: The use of pregabalin 150mg after surgery for two days significantly reduces the analgesic consumption

Keywords: Pregabalin, Postoperative analgesic, Numeric rating scale