A novel two-codon deletion at codon 508 and 509 of the rpoB gene in pulmonary tuberculosis and HIV co-infection: A case report

Lih Huey, Chua Wei Chuan, Zeti Norfidiyati Salmuna Ayub, Norazmi Mohd Nor, Alwi Muhd Besari and Chan, Yean Yean

doi:10.53350/pjmhs22167201

A novel two-codon deletion at codon 508 and 509 of the rpoB gene in pulmonary tuberculosis and HIV co-infection: A case report

Authors

Lih Huey, Chua Wei Chuan, Zeti Norfidiyati Salmuna Ayub, Norazmi Mohd Nor, Alwi Muhd Besari and Chan, Yean Yean

DOI:

https://doi.org/10.53350/pjmhs22167201

Abstract

We report a case of pulmonary Mycobacterium tuberculosis infection with a resistance to rifampicin (RIF) in a 39-year-old man who was co-infected with Human Immunodeficiency Virus (HIV) and hepatitis C. Phenotypic and genotypic test were performed to diagnose the patient. Sequencing analysis revealed novel two-codon deletion at codon 508 and 509 of the rpoB gene in M. tuberculosis.

Keywords: Co-infection, Mycobacterium tuberculosis, rpoB gene, rifampicin-resistant.

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How to Cite

Lih Huey, Chua Wei Chuan, Zeti Norfidiyati Salmuna Ayub, Norazmi Mohd Nor, Alwi Muhd Besari and Chan, Yean Yean. (2022). A novel two-codon deletion at codon 508 and 509 of the rpoB gene in pulmonary tuberculosis and HIV co-infection: A case report. Pakistan Journal of Medical & Health Sciences, 16(07), 201. https://doi.org/10.53350/pjmhs22167201