Frequency of Fetal Hemoglobin Level in Siblings of Betathalassemia Major patients

Authors

  • Nasir Rashid, Almas Raza, Syed Zeeshan Haider Naqvi, Sheema Khan

DOI:

https://doi.org/10.53350/pjmhs22167186

Abstract

Aim: To see the frequency of fetal haemoglobin level in siblings of beta thalassemia major (BTM) patients.

Study population: A total of 400 subjects were included.

Grouping: Group A includes normal siblings of BTM cases, B includes beta thalassemia trait (BTT) siblings of BTM cases and group C were healthy controls.

Selection criteria: Asymptomatic siblings of diagnosed cases of beta thalassemia major were included. Patients with history or diagnosis of any acute or chronic illnesses were excluded from the study. 5 ml of blood was taken in EDTA vial and used for haemoglobin electrophoresis. 

Results: In 200 cases, 78% (156) were beta thalassemia trait (BTT) siblings and fetal Hb was also more in BTT siblings i.e. Group B.

Conclusion: Fetal haemoglobin (HbF) was increased in BTT siblings (group B) of BTM cases.

Keywords: Hb electrophoresis, fetal Hb, beta thalassemia major

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How to Cite

Nasir Rashid, Almas Raza, Syed Zeeshan Haider Naqvi, Sheema Khan. (2022). Frequency of Fetal Hemoglobin Level in Siblings of Betathalassemia Major patients. Pakistan Journal of Medical & Health Sciences, 16(07), 186. https://doi.org/10.53350/pjmhs22167186

Issue

Vol. 16 No. 07 (2022): Pakistan Journal of Medical & Health Sciences

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Articles

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