Elevation of AST/ALT Ratio in Association with Severity of Esophageal Varices in Patients with Hepatic Cirrhosis

Authors

  • Imran Khan, Mukhtar Ahmad, Fahad Aman Khan, Muhammad Kashif, Tashia Malik, Aniqa Anser Tufail Khan

DOI:

https://doi.org/10.53350/pjmhs22165259

Keywords:

Elevation, AST/ALT ratio, Association, Esophageal varices, Hepatic cirrhosis

Abstract

Objective: To determine the elevation of AST/ALT ratio in association with severity of esophageal varices in patients with hepatic cirrhosis.

Study Design: Cross sectional survey

Place and Duration of Study: Medical Unit II, Jinnah Hospital Lahore from November 2018 to April 2019

Methodology: One hundred and ten subjects were enrolled. The complete history, physical examination and appropriate investigations were done like liver functions test to see the ratio of AST/ALT and upper GI Endoscopy to confirm the presence or absence of esophageal varices.

Results: The mean age of the patients was 45.6±5.2 years with 77.27% males and 22.73% females. Paquet grading system showed that esophageal varices were presented in 20.9% grade II. Within the 65 cases of esophageal varices 30 patients of liver cirrhosis were having a 27% high risk of esophageal varices. ALT and AST were significantly higher in high risk esophageal varices.

Conclusion: The elevated level of ALT and AST are significantly associated with the severity of esophageal varices in hepatic cirrhosispatients.

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How to Cite

Imran Khan, Mukhtar Ahmad, Fahad Aman Khan, Muhammad Kashif, Tashia Malik, Aniqa Anser Tufail Khan. (2022). Elevation of AST/ALT Ratio in Association with Severity of Esophageal Varices in Patients with Hepatic Cirrhosis. Pakistan Journal of Medical & Health Sciences, 16(05), 259. https://doi.org/10.53350/pjmhs22165259

Issue

Vol. 16 No. 05 (2022): Pakistan Journal of Medical & Health Sciences

Section

Articles

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